| 題名: | Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis |
| 作者: | Liao HF
Chen YY
Liu JJ
Hsu ML
Shieh HJ
Liao HJ
Shieh CJ
Shiao MS
Chen YJ |
| 貢獻者: | 國術系 |
| 關鍵詞: | CAPE (caffeic acid phenethyl ester)
angiogenesis
tumor invasion
metastasis
matrix metalloproteinase
human umbilical vein endothelial cell
vascular endothelial growth factor |
| 日期: | 2003 |
| 上傳時間: | 2009-11-30 11:00:23 (UTC+8) |
| 摘要: | Caffeic acid phenethyl ester (CAPE) derived from honeybee propolis has been used as a folk medicine and has several proven biological activities. The present study investigated the effect of CAPE on angiogenesis, tumor invasion, and metastasis. A cytotoxicity assay of CAPE in CT26 colon adenocarcinoma cells showed a dose-dependent decrease in cell viability but no significant influence on the growth of human umbilical vein epithelial cells (HUVEC). A low concentration of CAPE (1.5 mug/mL) inhibited 52.7% of capillary-like tube formation in HUVEC culture on Matrigel. CAPE (6 mug/mL)-treated CT26 cells showed not only inhibited cell invasion by 47.8% but also decreased expression of matrix metalloproteinase (MMP)-2 and -9. Vascular endothelial growth factor (VEGF) production from CT26 cells was also inhibited by treatment with CAPE (6 mug/mL). Intraperitoneal injection of CAPE (10 mg/kg/day) in BALB/c mice reduced the pulmonary metastatic capacity of CT26 cells accompanied with a decreased plasma VEGF level. CAPE treatment also prolonged the survival of mice implanted with CT26 cells. These results indicate that CAPE has potential as an antimetastatic agent. |
| 關聯: | JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Volume: 51 Issue: 27 Pages: 7907-7912 |
| 顯示於類別: | [技擊運動暨國術學系] 期刊論文
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