Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis

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Title:	Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis
Authors:	Liao HF Chen YY Liu JJ Hsu ML Shieh HJ Liao HJ Shieh CJ Shiao MS Chen YJ
Contributors:	國術系
Keywords:	CAPE (caffeic acid phenethyl ester) angiogenesis tumor invasion metastasis matrix metalloproteinase human umbilical vein endothelial cell vascular endothelial growth factor
Date:	2003
Issue Date:	2009-11-30 11:00:23 (UTC+8)
Abstract:	Caffeic acid phenethyl ester (CAPE) derived from honeybee propolis has been used as a folk medicine and has several proven biological activities. The present study investigated the effect of CAPE on angiogenesis, tumor invasion, and metastasis. A cytotoxicity assay of CAPE in CT26 colon adenocarcinoma cells showed a dose-dependent decrease in cell viability but no significant influence on the growth of human umbilical vein epithelial cells (HUVEC). A low concentration of CAPE (1.5 mug/mL) inhibited 52.7% of capillary-like tube formation in HUVEC culture on Matrigel. CAPE (6 mug/mL)-treated CT26 cells showed not only inhibited cell invasion by 47.8% but also decreased expression of matrix metalloproteinase (MMP)-2 and -9. Vascular endothelial growth factor (VEGF) production from CT26 cells was also inhibited by treatment with CAPE (6 mug/mL). Intraperitoneal injection of CAPE (10 mg/kg/day) in BALB/c mice reduced the pulmonary metastatic capacity of CT26 cells accompanied with a decreased plasma VEGF level. CAPE treatment also prolonged the survival of mice implanted with CT26 cells. These results indicate that CAPE has potential as an antimetastatic agent.
Relation:	JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Volume: 51 Issue: 27 Pages: 7907-7912
Appears in Collections:	[Department of Chinese Martial Arts] journal articles

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