文化大學機構典藏 CCUR:Item 987654321/2897
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/2897


    题名: Inhibitory effect of caffeic acid phenethyl ester on angiogenesis, tumor invasion, and metastasis
    作者: Liao HF
    Chen YY
    Liu JJ
    Hsu ML
    Shieh HJ
    Liao HJ
    Shieh CJ
    Shiao MS
    Chen YJ
    贡献者: 國術系
    关键词: CAPE (caffeic acid phenethyl ester)
    angiogenesis
    tumor invasion
    metastasis
    matrix metalloproteinase
    human umbilical vein endothelial cell
    vascular endothelial growth factor
    日期: 2003
    上传时间: 2009-11-30 11:00:23 (UTC+8)
    摘要: Caffeic acid phenethyl ester (CAPE) derived from honeybee propolis has been used as a folk medicine and has several proven biological activities. The present study investigated the effect of CAPE on angiogenesis, tumor invasion, and metastasis. A cytotoxicity assay of CAPE in CT26 colon adenocarcinoma cells showed a dose-dependent decrease in cell viability but no significant influence on the growth of human umbilical vein epithelial cells (HUVEC). A low concentration of CAPE (1.5 mug/mL) inhibited 52.7% of capillary-like tube formation in HUVEC culture on Matrigel. CAPE (6 mug/mL)-treated CT26 cells showed not only inhibited cell invasion by 47.8% but also decreased expression of matrix metalloproteinase (MMP)-2 and -9. Vascular endothelial growth factor (VEGF) production from CT26 cells was also inhibited by treatment with CAPE (6 mug/mL). Intraperitoneal injection of CAPE (10 mg/kg/day) in BALB/c mice reduced the pulmonary metastatic capacity of CT26 cells accompanied with a decreased plasma VEGF level. CAPE treatment also prolonged the survival of mice implanted with CT26 cells. These results indicate that CAPE has potential as an antimetastatic agent.
    關聯: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY Volume: 51 Issue: 27 Pages: 7907-7912
    显示于类别:[技擊運動暨國術學系] 期刊論文

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