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https://irlib.pccu.edu.tw/handle/987654321/53187
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| 題名: | α-Viniferin-Induced Apoptosis through Downregulation of SIRT1 in Non-Small Cell Lung Cancer Cells |
| 作者: | Huang, Cheng
Lin, Zi-Jun
Chen, Jui-Chieh
Zheng, Hao-Jun
Lai, Yu-Heng
Huang, Hsiu-Chen
賴昱衡 |
| 貢獻者: | Department of Chemistry |
| 關鍵詞: | apoptosis
NCI-H460 cells
non-small cell lung cancer
nude mice
α-Viniferin |
| 日期: | 2023-05 |
| 上傳時間: | 2024-03-12 15:10:33 (UTC+8) |
| 出版者: | Multidisciplinary Digital Publishing Institute |
| 摘要: | α-Viniferin, a natural stilbene compound found in plants and a polymer of resveratrol, had demonstrated potential anti-cancer and anti-inflammatory effects. However, the specific mechanisms underlying its anti-cancer activity were not yet fully understood and required further investigation. This study evaluated the effectiveness of α-viniferin and ε-viniferin using MTT assay. Results showed that α-viniferin was more effective than ε-viniferin in reducing the viability of NCI-H460 cells, a type of non-small cell lung cancer. Annexin V/7AAD assay results provided further evidence that the decrease in cell viability observed in response to α-viniferin treatment was due to the induction of apoptosis in NCI-H460 cells. The present findings indicated that treatment with α-viniferin could stimulate apoptosis in cells by cleaving caspase 3 and PARP. Moreover, the treatment reduced the expression of SIRT1, vimentin, and phosphorylated AKT, and also induced AIF nuclear translocation. Furthermore, this research provided additional evidence for the effectiveness of α-viniferin as an anti-tumor agent in nude mice with NCI-H460 cell xenografts. As demonstrated by the TUNEL assay results, α-viniferin promoted apoptosis in NCI-H460 cells in nude mice. |
| 關聯: | Pharmaceuticals |
| 顯示於類別: | [化學系所] 期刊論文
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