文化大學機構典藏 CCUR:Item 987654321/53187
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/53187


    题名: α-Viniferin-Induced Apoptosis through Downregulation of SIRT1 in Non-Small Cell Lung Cancer Cells
    作者: Huang, Cheng
    Lin, Zi-Jun
    Chen, Jui-Chieh
    Zheng, Hao-Jun
    Lai, Yu-Heng
    Huang, Hsiu-Chen
    賴昱衡
    贡献者: Department of Chemistry
    关键词: apoptosis
    NCI-H460 cells
    non-small cell lung cancer
    nude mice
    α-Viniferin
    日期: 2023-05
    上传时间: 2024-03-12 15:10:33 (UTC+8)
    出版者: Multidisciplinary Digital Publishing Institute
    摘要: α-Viniferin, a natural stilbene compound found in plants and a polymer of resveratrol, had demonstrated potential anti-cancer and anti-inflammatory effects. However, the specific mechanisms underlying its anti-cancer activity were not yet fully understood and required further investigation. This study evaluated the effectiveness of α-viniferin and ε-viniferin using MTT assay. Results showed that α-viniferin was more effective than ε-viniferin in reducing the viability of NCI-H460 cells, a type of non-small cell lung cancer. Annexin V/7AAD assay results provided further evidence that the decrease in cell viability observed in response to α-viniferin treatment was due to the induction of apoptosis in NCI-H460 cells. The present findings indicated that treatment with α-viniferin could stimulate apoptosis in cells by cleaving caspase 3 and PARP. Moreover, the treatment reduced the expression of SIRT1, vimentin, and phosphorylated AKT, and also induced AIF nuclear translocation. Furthermore, this research provided additional evidence for the effectiveness of α-viniferin as an anti-tumor agent in nude mice with NCI-H460 cell xenografts. As demonstrated by the TUNEL assay results, α-viniferin promoted apoptosis in NCI-H460 cells in nude mice.
    關聯: Pharmaceuticals
    显示于类别:[化學系所] 期刊論文

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