Covid-19 had an adverse impact on the world's banking sector, particularly in the United States, which lead to decline profitability. This study applies Independent Samples T-Test model on data spanning January 2019, to December 2021 to analyze and compare the effects of the Covid-19 epidemic on the bank performance in the United States both before and after the outbreak. Secondary data was obtained from the Refinitiv–Thomson Reuter Database using five financial ratios (ROA, ROE, NIM, CAR, NPL) for top 8 banking companies in the U.S ranked by total assets. The results show that there are variations between the ROA, NIM, and CAR variables before and after the epidemic. While there is no difference between the ROE and NPL variables in the time before and after the epidemic. The finding of this study can be a useful tool for current and prospective investors when making investment decisions during the current Covid-19 outbreak situation. The results can also be used by policymakers as one of the informational resources for developing regulations to bolster upcoming bank defenses in the United States.