資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://irlib.pccu.edu.tw/handle/987654321/49506
|
| 題名: | Novel Application of Magnetite Nanoparticle-Mediated Vitamin D3 Delivery for Peritoneal Dialysis-Related Peritoneal Damage |
| 作者: | Cheng, FY (Cheng, Fong-Yu)
Chiou, YY (Chiou, Yuan-Yow)
Hung, SY (Hung, Shih-Yuan)
Lin, TM (Lin, Tsun-Mei)
Wang, HK (Wang, Hao-Kuang)
Lin, CW (Lin, Chi-Wei)
Liou, HH (Liou, Hung-Hsiang)
Chang, MY (Chang, Min-Yu)
Wang, HH (Wang, Hsi-Hao)
Lee, YC (Lee, Yi-Che) |
| 貢獻者: | 化學系 |
| 關鍵詞: | peritoneal dialysis
nanoparticles
vitamin D
fibrosis |
| 日期: | 2021 |
| 上傳時間: | 2021-04-22 12:57:02 (UTC+8) |
| 摘要: | Purpose: Vitamin D3 is useful for the treatment of peritoneal dialysis (PD)-related peritoneal damage, but its side effects, such as hypercalcemia and vascular calcification, limit its applicability. Thus, we developed vitamin D-loaded magnetic nanoparticles (MNPs) and determined their therapeutic efficacy and side effects in vivo. Materials and Methods: Alginate-modified MNPs were combined with 1 alpha, 25 (OH)2D3 to generate vitamin D-loaded nanoparticles. The particles were conjugated with an antibody against peritoneum-glycoprotein M6A (GPM6A). The particles' ability to target the peritoneum was examined following intraperitoneal administration to mice and by monitoring their bio-distribution. We also established a PD animal model to determine the therapeutic and side effects of vitamin D-loaded MNPs in vivo. Results: Vitamin D-loaded MNPs targeted the peritoneum better than vitamin D3, and had the same therapeutic effect as vitamin D3 in ameliorating peritoneal fibrosis and functional deterioration in a PD animal model. Most importantly, the particles reduced the side effects of vitamin D3, such as hypercalcemia and body weight loss, in mice. Conclusion: Vitamin D-loaded MNPs could be an ideal future therapeutic option to treat PD-related peritoneal damage. |
| 關聯: | INTERNATIONAL JOURNAL OF NANOMEDICINE 卷冊: 16 頁數: 2137-2146 |
| 顯示於類別: | [化學系所] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 308 | 檢視/開啟 |
|
在CCUR中所有的資料項目都受到原著作權保護.
|
