Novel Application of Magnetite Nanoparticle-Mediated Vitamin D3 Delivery for Peritoneal Dialysis-Related Peritoneal Damage

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Title:	Novel Application of Magnetite Nanoparticle-Mediated Vitamin D3 Delivery for Peritoneal Dialysis-Related Peritoneal Damage
Authors:	Cheng, FY (Cheng, Fong-Yu) Chiou, YY (Chiou, Yuan-Yow) Hung, SY (Hung, Shih-Yuan) Lin, TM (Lin, Tsun-Mei) Wang, HK (Wang, Hao-Kuang) Lin, CW (Lin, Chi-Wei) Liou, HH (Liou, Hung-Hsiang) Chang, MY (Chang, Min-Yu) Wang, HH (Wang, Hsi-Hao) Lee, YC (Lee, Yi-Che)
Contributors:	化學系
Keywords:	peritoneal dialysis nanoparticles vitamin D fibrosis
Date:	2021
Issue Date:	2021-04-22 12:57:02 (UTC+8)
Abstract:	Purpose: Vitamin D3 is useful for the treatment of peritoneal dialysis (PD)-related peritoneal damage, but its side effects, such as hypercalcemia and vascular calcification, limit its applicability. Thus, we developed vitamin D-loaded magnetic nanoparticles (MNPs) and determined their therapeutic efficacy and side effects in vivo. Materials and Methods: Alginate-modified MNPs were combined with 1 alpha, 25 (OH)2D3 to generate vitamin D-loaded nanoparticles. The particles were conjugated with an antibody against peritoneum-glycoprotein M6A (GPM6A). The particles' ability to target the peritoneum was examined following intraperitoneal administration to mice and by monitoring their bio-distribution. We also established a PD animal model to determine the therapeutic and side effects of vitamin D-loaded MNPs in vivo. Results: Vitamin D-loaded MNPs targeted the peritoneum better than vitamin D3, and had the same therapeutic effect as vitamin D3 in ameliorating peritoneal fibrosis and functional deterioration in a PD animal model. Most importantly, the particles reduced the side effects of vitamin D3, such as hypercalcemia and body weight loss, in mice. Conclusion: Vitamin D-loaded MNPs could be an ideal future therapeutic option to treat PD-related peritoneal damage.
Relation:	INTERNATIONAL JOURNAL OF NANOMEDICINE 卷冊: 16 頁數: 2137-2146
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

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