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https://irlib.pccu.edu.tw/handle/987654321/49470
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| 題名: | Effect of extremely low frequency electromagnetic field parameters on the proliferation of human breast cancer |
| 作者: | Wang, MH (Wang, Min-Haw)
Chen, KW (Chen, Kuan-Wei)
Ni, DX (Ni, Ding-Xung)
Fang, HJ (Fang, Hao-Jha)
Jang, LS (Jang, Ling-Sheng)
Chen, CH (Chen, Chun-Hong) |
| 貢獻者: | 電機系 |
| 關鍵詞: | Extremely low frequency electromagnetic field (ELF-EMF)
MDA-MB-231
MCF-7
M10 |
| 日期: | 2021-02 |
| 上傳時間: | 2021-04-14 14:11:38 (UTC+8) |
| 摘要: | Extremely low-frequency electromagnetic field (ELF-EMF) exposures influence many biological systems. These effects are mainly related to the intensity, duration, frequency, and pattern of the ELF-EMF. Our intent was to characterize the effect of specific pulsed electromagnetic fields on the in vitro proliferation of MCF-7 adenocarcinoma and MDA-MB-231 breast cancer cell lines and one non-cancerous M10 breast epithelial cell line. The following four important parameters of ELF-EMF were examined: frequencies (7.83 +/- 0.3, 23.49 +/- 0.3, and 39.15 +/- 0.3 Hz), flux density (0.5 and 1 mT), exposure duration (12, 24, and 48 h), and the exposure methodology (continuous exposure versus switching exposure). The viability of MDA-MB-231 cells exposed to the optimized ELF-EMF pattern (7.83 +/- 0.3 Hz, 1 mT, and 6 h switching exposure) was 40.1%. By contrast, the optimized ELF-EMF parameters that were most cytotoxic to breast cancer MDA-MB-231 cells were not damaging to normal M10 cells. In vitro studies also showed that exposure of MDA-MB-231 cells to the optimized ELF-EMF pattern promoted Ca2+ influx and resulted in apoptosis. These data confirm that exposure to this specific ELF-EMF pattern can influence cellular processes and inhibit cancer cell growth. The specific ELF-EMF pattern determined in this study may provide a potential anti-cancer treatment in the future. |
| 關聯: | ELECTROMAGNETIC BIOLOGY AND MEDICINE 早期取閱: FEB 2021 |
| 顯示於類別: | [電機工程系] 期刊論文
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