文化大學機構典藏 CCUR:Item 987654321/49470
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    题名: Effect of extremely low frequency electromagnetic field parameters on the proliferation of human breast cancer
    作者: Wang, MH (Wang, Min-Haw)
    Chen, KW (Chen, Kuan-Wei)
    Ni, DX (Ni, Ding-Xung)
    Fang, HJ (Fang, Hao-Jha)
    Jang, LS (Jang, Ling-Sheng)
    Chen, CH (Chen, Chun-Hong)
    贡献者: 電機系
    关键词: Extremely low frequency electromagnetic field (ELF-EMF)
    MDA-MB-231
    MCF-7
    M10
    日期: 2021-02
    上传时间: 2021-04-14 14:11:38 (UTC+8)
    摘要: Extremely low-frequency electromagnetic field (ELF-EMF) exposures influence many biological systems. These effects are mainly related to the intensity, duration, frequency, and pattern of the ELF-EMF. Our intent was to characterize the effect of specific pulsed electromagnetic fields on the in vitro proliferation of MCF-7 adenocarcinoma and MDA-MB-231 breast cancer cell lines and one non-cancerous M10 breast epithelial cell line. The following four important parameters of ELF-EMF were examined: frequencies (7.83 +/- 0.3, 23.49 +/- 0.3, and 39.15 +/- 0.3 Hz), flux density (0.5 and 1 mT), exposure duration (12, 24, and 48 h), and the exposure methodology (continuous exposure versus switching exposure). The viability of MDA-MB-231 cells exposed to the optimized ELF-EMF pattern (7.83 +/- 0.3 Hz, 1 mT, and 6 h switching exposure) was 40.1%. By contrast, the optimized ELF-EMF parameters that were most cytotoxic to breast cancer MDA-MB-231 cells were not damaging to normal M10 cells. In vitro studies also showed that exposure of MDA-MB-231 cells to the optimized ELF-EMF pattern promoted Ca2+ influx and resulted in apoptosis. These data confirm that exposure to this specific ELF-EMF pattern can influence cellular processes and inhibit cancer cell growth. The specific ELF-EMF pattern determined in this study may provide a potential anti-cancer treatment in the future.
    關聯: ELECTROMAGNETIC BIOLOGY AND MEDICINE 早期取閱: FEB 2021
    显示于类别:[電機工程系] 期刊論文

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