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https://irlib.pccu.edu.tw/handle/987654321/48821
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| 題名: | Inhibition of B16F10 Cancer Cell Growth by Exposure to the Square Wave with 7.83+/-0.3Hz Involves L- and T-Type Calcium Channels |
| 作者: | Wang, MH (Wang, Min-Haw)
Jian, MW (Jian, Ming-Wei)
Tai, YH (Tai, Yuan-Hsuan)
Jang, LS (Jang, Ling-Sheng)
Chen, CH (Chen, Chun-Hong |
| 貢獻者: | 電機系 |
| 關鍵詞: | Extremely low-frequency electromagnetic field (ELF-EMF)
voltage-gated L
and T-type Ca2+ channel |
| 日期: | 2020-10 |
| 上傳時間: | 2020-11-12 09:36:40 (UTC+8) |
| 摘要: | Extremely low-frequency electromagnetic field (ELF-EMF) exposure influences many biological systems; these effects are mainly related to the intensity, duration, frequency, and pattern of the ELF-EMF. In this study, exposure to square wave with 7.83 +/- 0.3 Hz (sweep step 0.1 Hz) was shown to inhibit the growth of B16F10 melanoma tumor cells. In addition, the distribution of the magnetic field was calculated by Biot-Savart Law and plotted using MATLAB. In vitro studies demonstrated a decrease in B16F10 cell proliferation and an increase of Ca2+ influx after 48 h of exposure to the square wave. Ca2+ influx was also partially blocked by inhibition of voltage-gated L- and T-type Ca2+ channels. The data confirmed that the specific time-varying ELF-EMF had an anti-proliferation effect on B16F10 cells and that the inhibition is related to Ca2+ and voltage-gated L- and T-type Ca2+ channels. |
| 關聯: | ELECTROMAGNETIC BIOLOGY AND MEDICINE 早期取閱: OCT 2020 |
| 顯示於類別: | [電機工程系] 期刊論文
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