Inhibition of B16F10 Cancer Cell Growth by Exposure to the Square Wave with 7.83+/-0.3Hz Involves L- and T-Type Calcium Channels

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Title:	Inhibition of B16F10 Cancer Cell Growth by Exposure to the Square Wave with 7.83+/-0.3Hz Involves L- and T-Type Calcium Channels
Authors:	Wang, MH (Wang, Min-Haw) Jian, MW (Jian, Ming-Wei) Tai, YH (Tai, Yuan-Hsuan) Jang, LS (Jang, Ling-Sheng) Chen, CH (Chen, Chun-Hong
Contributors:	電機系
Keywords:	Extremely low-frequency electromagnetic field (ELF-EMF) voltage-gated L and T-type Ca2+ channel
Date:	2020-10
Issue Date:	2020-11-12 09:36:40 (UTC+8)
Abstract:	Extremely low-frequency electromagnetic field (ELF-EMF) exposure influences many biological systems; these effects are mainly related to the intensity, duration, frequency, and pattern of the ELF-EMF. In this study, exposure to square wave with 7.83 +/- 0.3 Hz (sweep step 0.1 Hz) was shown to inhibit the growth of B16F10 melanoma tumor cells. In addition, the distribution of the magnetic field was calculated by Biot-Savart Law and plotted using MATLAB. In vitro studies demonstrated a decrease in B16F10 cell proliferation and an increase of Ca2+ influx after 48 h of exposure to the square wave. Ca2+ influx was also partially blocked by inhibition of voltage-gated L- and T-type Ca2+ channels. The data confirmed that the specific time-varying ELF-EMF had an anti-proliferation effect on B16F10 cells and that the inhibition is related to Ca2+ and voltage-gated L- and T-type Ca2+ channels.
Relation:	ELECTROMAGNETIC BIOLOGY AND MEDICINE 早期取閱: OCT 2020
Appears in Collections:	[Department of Electrical Engineering ] journal articles

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