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| 題名: | Aqueous Extract of Tournefortia sarmentosa Stem Inhibits ADP-induced Platelet Aggregation |
| 作者: | Wang, LK (Wang, L. K.)
Tsai, FM (Tsai, F. M.)
Wu, S (Wu, S.)
Lee, MC (Lee, M. C.)
Tsai, TC (Tsai, T. C.)
Chou, WM (Chou, Weimou)
Wang, CH (Wang, C. H.) |
| 貢獻者: | 生命科學系 |
| 關鍵詞: | P2Y(12) RECEPTOR
SALVIANOLIC ACID
CAFFEIC ACID
WHOLE-BLOOD
ACTIVATION
MECHANISM
THROMBOSIS
ASPIRIN
ANIMALS |
| 日期: | 2018 |
| 上傳時間: | 2019-01-22 14:33:16 (UTC+8) |
| 摘要: | Tournefortia sarmentosa is a Chinese herbal medicine used as an antioxidant, detoxicant, and antiinflammatory agent. The present study evaluated the effect of T. sarmentosa on adenosine diphosphate-induced platelet aggregation. Our results showed that aqueous stem extract of T. sarmentosa inhibited adenosine diphosphate-induced platelet aggregation. In addition, we found components in T. sarmentosa, including caffeic acid, rosmarinic acid, salvianolic acid, play important roles in mediating adenosine diphosphate-induced platelet aggregation suppression. The stem extract of T. sarmentosa inhibited the adenosine diphosphate receptor P2Y(12)-mediated cyclic AMP production. Caffeic acid inhibited P2Y(1)-induced calcium influx. Furthermore, treatment of platelets with T. sarmentosa, or the components in stem extract of T. sarmentosa, suppressed adenosine diphosphate-induced release of thromboxane A2 and arachidonic acid and surface PAC-1 expression. These data demonstrate the aqueous stem extract of T. sarmentosa significantly suppressed platelet aggregation through P2Y(1) and P2Y(12) receptor signal pathways. The antiaggregation properties found in the stem extract of T. sarmentosa might help to prevent cardiovascular disease. |
| 顯示於類別: | [生命科學系] 期刊論文
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