Aqueous Extract of Tournefortia sarmentosa Stem Inhibits ADP-induced Platelet Aggregation

CCUR > College of Natural Science and Engineering > College of Science > Department of Biology > journal articles > Item 987654321/41948

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/41948

题名:	Aqueous Extract of Tournefortia sarmentosa Stem Inhibits ADP-induced Platelet Aggregation
作者:	Wang, LK (Wang, L. K.) Tsai, FM (Tsai, F. M.) Wu, S (Wu, S.) Lee, MC (Lee, M. C.) Tsai, TC (Tsai, T. C.) Chou, WM (Chou, Weimou) Wang, CH (Wang, C. H.)
贡献者:	生命科學系
关键词:	P2Y(12) RECEPTOR SALVIANOLIC ACID CAFFEIC ACID WHOLE-BLOOD ACTIVATION MECHANISM THROMBOSIS ASPIRIN ANIMALS
日期:	2018
上传时间:	2019-01-22 14:33:16 (UTC+8)
摘要:	Tournefortia sarmentosa is a Chinese herbal medicine used as an antioxidant, detoxicant, and antiinflammatory agent. The present study evaluated the effect of T. sarmentosa on adenosine diphosphate-induced platelet aggregation. Our results showed that aqueous stem extract of T. sarmentosa inhibited adenosine diphosphate-induced platelet aggregation. In addition, we found components in T. sarmentosa, including caffeic acid, rosmarinic acid, salvianolic acid, play important roles in mediating adenosine diphosphate-induced platelet aggregation suppression. The stem extract of T. sarmentosa inhibited the adenosine diphosphate receptor P2Y(12)-mediated cyclic AMP production. Caffeic acid inhibited P2Y(1)-induced calcium influx. Furthermore, treatment of platelets with T. sarmentosa, or the components in stem extract of T. sarmentosa, suppressed adenosine diphosphate-induced release of thromboxane A2 and arachidonic acid and surface PAC-1 expression. These data demonstrate the aqueous stem extract of T. sarmentosa significantly suppressed platelet aggregation through P2Y(1) and P2Y(12) receptor signal pathways. The antiaggregation properties found in the stem extract of T. sarmentosa might help to prevent cardiovascular disease.
显示于类别:	[Department of Biology ] journal articles

文件中的档案:

档案	描述	大小	格式	浏览次数
index.html		0Kb	HTML	381	检视/开启

检视Licence

在CCUR中所有的数据项都受到原著作权保护.

数据加载中.....