Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction

文化大學機構典藏 CCUR > 環境規劃暨生物資源學院 > 農學院 > 生物科技研究所 > 期刊論文 > Item 987654321/36128

Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/36128

Title:	Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction
Authors:	Thuy, TD (Tran Duong Thuy) Phan, NN (Nam Nhut Phan) Wang, CY (Wang, Chih-Yang) Yu, HG (Yu, Han-Gang) Wang, SY (Wang, Shu-Yin) Huang, PL (Huang, Pung-Ling) Do, YY (Do, Yi-Yin) Lin, YC (Lin, Yen-Chang)
Contributors:	生科所
Keywords:	Sesamin cardiac dysfunction diabetes
Date:	2017-05
Issue Date:	2017-06-08 09:49:42 (UTC+8)
Abstract:	Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication.
Relation:	MOLECULAR MEDICINE REPORTS 卷: 15 期: 5頁碼: 2949-2956
Appears in Collections:	[生物科技研究所 ] 期刊論文

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