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https://irlib.pccu.edu.tw/handle/987654321/36128
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| Title: | Novel therapeutic effects of sesamin on diabetes-induced cardiac dysfunction |
| Authors: | Thuy, TD (Tran Duong Thuy)
Phan, NN (Nam Nhut Phan)
Wang, CY (Wang, Chih-Yang)
Yu, HG (Yu, Han-Gang)
Wang, SY (Wang, Shu-Yin)
Huang, PL (Huang, Pung-Ling)
Do, YY (Do, Yi-Yin)
Lin, YC (Lin, Yen-Chang) |
| Contributors: | 生科所 |
| Keywords: | Sesamin
cardiac dysfunction
diabetes |
| Date: | 2017-05 |
| Issue Date: | 2017-06-08 09:49:42 (UTC+8) |
| Abstract: | Diabetes is a risk factor that increases the occurrence and severity of cardiovascular events. Cardiovascular complications are the leading cause of mortality of 75% of patients with diabetes >40 years old. Sesamin, the bioactive compound extracted from Sesamum indicum, is a natural compound that has diverse beneficial effects on hypoglycemia and reducing cholesterol. The aim of this study is to investigate sesamin effects to diabetes-inducing cardiac hypertrophy. In the present study bioinformatics analysis demonstrated cardiac hypertrophy signaling may be the most important pathway for upregulating genes in sesamin-treated groups. To verify the bioinformatics prediction, sesamin was used as the main bioactive compound to attenuate the impact of diabetes induced by streptozotocin (STZ) on cardiac function in a rat model. The results revealed that oral administration of sesamin for 4 weeks (100 and 200 mg/kg body weight) marginally improved blood glucose levels, body weight and significantly ameliorated the effects on heart rate and blood pressure in rats with type 1 diabetes relative to control rats. The QT interval of sesamin was also reduced relative to the control group. The findings indicated that sesamin has potential cardioprotective effects in the STZ-induced diabetes model. This suggested that this can be used as a novel treatment for patients with diabetes with cardiac dysfunction complication. |
| Relation: | MOLECULAR MEDICINE REPORTS 卷: 15 期: 5頁碼: 2949-2956 |
| Appears in Collections: | [Graduate Institute of Biotechnology ] journal articles
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