資料載入中.....
|
請使用永久網址來引用或連結此文件:
https://irlib.pccu.edu.tw/handle/987654321/35950
|
| 題名: | Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells |
| 作者: | Hwang, PA (Hwang, Pai-An)
Phan, NN (Nam Nhut Phan)
Lu, WJ (Lu, Wen-Jung)
Hieu, BTN (Bui Thi Ngoc Hieu)
Lin, YC (Lin, Yen-Chang) |
| 貢獻者: | 生科所 |
| 關鍵詞: | low-molecular-weight fucoidan
fucoxanthin
anti-inflammatory
prebiotics |
| 日期: | 2016 |
| 上傳時間: | 2017-04-17 11:32:18 (UTC+8) |
| 摘要: | Background: The aim of this study is to investigate the anti-inflammatory effects of low-molecular-weight fucoidan (LMF) and high-stability fucoxanthin (HS-Fucox) in a lipopolysaccharide-induced inflammatory Caco-2 cell line co-culture with B. lactis.
Methods: We used various methods such as transepithelial resistance (TER) assay, cytokine secretion assay, and tight junction protein mRNA expression assay to examine LMF and HS-Fucox anti-inflammatory properties.
Results: LMF and HS-Fucox activated probiotic growth and reduced the inflammation of the intestinal epithelial cells. Moreover, the combination of LMFHS-Fucox dramatically enhanced the intestinal epithelial barrier and immune function against the lipopolysaccharide effect by inhibiting IL-1 beta and TNF-alpha and promoting IL-10 and IFN-gamma.
Conclusion: These findings suggested that LMF and HS-Fucox, alone or in combination, could be the potential natural compounds to enhance the immune system and have an anti-inflammatory effect on the intestinal cells. |
| 關聯: | FOOD & NUTRITION RESEARCH 卷: 60 文獻號碼: 32033 |
| 顯示於類別: | [生物科技研究所 ] 期刊論文
|
文件中的檔案:
| 檔案 |
描述 |
大小 | 格式 | 瀏覽次數 |
|---|
| index.html | | 0Kb | HTML | 308 | 檢視/開啟 |
|
在CCUR中所有的資料項目都受到原著作權保護.
|
