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https://irlib.pccu.edu.tw/handle/987654321/35950
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| Title: | Low-molecular-weight fucoidan and high-stability fucoxanthin from brown seaweed exert prebiotics and anti-inflammatory activities in Caco-2 cells |
| Authors: | Hwang, PA (Hwang, Pai-An)
Phan, NN (Nam Nhut Phan)
Lu, WJ (Lu, Wen-Jung)
Hieu, BTN (Bui Thi Ngoc Hieu)
Lin, YC (Lin, Yen-Chang) |
| Contributors: | 生科所 |
| Keywords: | low-molecular-weight fucoidan
fucoxanthin
anti-inflammatory
prebiotics |
| Date: | 2016 |
| Issue Date: | 2017-04-17 11:32:18 (UTC+8) |
| Abstract: | Background: The aim of this study is to investigate the anti-inflammatory effects of low-molecular-weight fucoidan (LMF) and high-stability fucoxanthin (HS-Fucox) in a lipopolysaccharide-induced inflammatory Caco-2 cell line co-culture with B. lactis.
Methods: We used various methods such as transepithelial resistance (TER) assay, cytokine secretion assay, and tight junction protein mRNA expression assay to examine LMF and HS-Fucox anti-inflammatory properties.
Results: LMF and HS-Fucox activated probiotic growth and reduced the inflammation of the intestinal epithelial cells. Moreover, the combination of LMFHS-Fucox dramatically enhanced the intestinal epithelial barrier and immune function against the lipopolysaccharide effect by inhibiting IL-1 beta and TNF-alpha and promoting IL-10 and IFN-gamma.
Conclusion: These findings suggested that LMF and HS-Fucox, alone or in combination, could be the potential natural compounds to enhance the immune system and have an anti-inflammatory effect on the intestinal cells. |
| Relation: | FOOD & NUTRITION RESEARCH 卷: 60 文獻號碼: 32033 |
| Appears in Collections: | [Graduate Institute of Biotechnology ] journal articles
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