Type 1 diabetes (T1D) is also called insulin-dependent diabetes or autoimmune
diabetes. In particular, the pancreas produces insufficient insulin or because cells do not
use insulin, which makes blood glucose and urine glucose increase. Diabetes is a risk
factor to increase the occurrence and severity of cardiovascular events. According to
statistics, cardiovascular complications are the leading cause of death of 3/4 of the
number of diabetic patients over 40 years old. Sesame (Sesamum indicum) is one of
natural medicine which has been known with many functions for good health. Sesamin -
a lignan extracted from the sesame seed - has many beneficial effects such as
hypoglycemia, ameliorate lipid metabolism, antioxidant and hypolipidemic activity,
reduced cholesterol, and anti-inflammatory activity. In this study, after oral
administration of sesamin extract for four week, all the diabetes subjects underwent to
blood glucose test, heart rate (HR), electrocardiography (ECG), blood pressure,
hematoxylin and eosin stain to observe the effect of sesamin on diabetes.
Sesamin consuming slightly improved blood glucose levels in rats with type 1
diabetes. But it significantly ameliorated HR, blood pressure (BP) and QT interval in
male diabetes rats. This indicated that sesamin has a positive effect on reducing
cardiovascular complications in diabetic animals.
