芝麻素對改善第 I型糖尿病大鼠心臟功能異常之研究

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Title:	芝麻素對改善第 I型糖尿病大鼠心臟功能異常之研究 Novel Therapeutic Effects of Sesamin on Type 1 Diabetes-induced Cardiac Dysfunction
Authors:	陳雲玉 Tran, Duong Thuy
Contributors:	生物科技研究所
Keywords:	Type 1 diabetes, sesamin cardiovascular dysfunction
Date:	2014-06
Issue Date:	2014-10-07 17:39:57 (UTC+8)
Abstract:	Type 1 diabetes (T1D) is also called insulin-dependent diabetes or autoimmune diabetes. In particular, the pancreas produces insufficient insulin or because cells do not use insulin, which makes blood glucose and urine glucose increase. Diabetes is a risk factor to increase the occurrence and severity of cardiovascular events. According to statistics, cardiovascular complications are the leading cause of death of 3/4 of the number of diabetic patients over 40 years old. Sesame (Sesamum indicum) is one of natural medicine which has been known with many functions for good health. Sesamin - a lignan extracted from the sesame seed - has many beneficial effects such as hypoglycemia, ameliorate lipid metabolism, antioxidant and hypolipidemic activity, reduced cholesterol, and anti-inflammatory activity. In this study, after oral administration of sesamin extract for four week, all the diabetes subjects underwent to blood glucose test, heart rate (HR), electrocardiography (ECG), blood pressure, hematoxylin and eosin stain to observe the effect of sesamin on diabetes. Sesamin consuming slightly improved blood glucose levels in rats with type 1 diabetes. But it significantly ameliorated HR, blood pressure (BP) and QT interval in male diabetes rats. This indicated that sesamin has a positive effect on reducing cardiovascular complications in diabetic animals.
Appears in Collections:	[Graduate Institute of Biotechnology ] thesis

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