文化大學機構典藏 CCUR:Item 987654321/2784
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    題名: Modulation of monocyte-derived dendritic cell differentiation is associated with ischemic acute renal failure
    作者: Wu CJ
    Sheu JR
    Chen HH
    Liao HF
    Yang YC
    Yang S
    Chen YJ
    貢獻者: 運教所
    關鍵詞: dendritic cells
    ischemia-reperfusion injury
    differentiation
    日期: 2006
    上傳時間: 2009-11-20 14:27:20 (UTC+8)
    摘要: Background. Dendritic cells (DCs) play a central role in both stimulating and suppressing immune responses and are impacted by surgical injury, exercise, and other physiological stressors. This study aims to determine whether renal ischemia/reperfusion (L/R) injury alters the differentiation, maturation, and activation of DCs from peripheral blood monocytes (PBMo).
    Materials and methods. Sprague-Dawley (SD) rats were subjected to I/R injury or sham-operated. Creatinine clearance (CCr) was monitored daily during the 14 days of reperfusion that followed the ischemic insult. At 2 and 14 days of reperfusion, the following properties of PBMo derived-DCs were assessed: the amount of generated DCs, surface markers [CD11c, CD80, CD86, and MHC-11 (IA)], and functional status including magnitude of mixed lymphocyte reaction (MLR), production of IL-12 p70 by DCs, and production of IFN-gamma and IL-4 by DC-stimulated T cells.

    Results. CCr was greatly reduced in the injured rats 0 to 4 days after ischemia. Two days after I/R injury to kidney, the numbers of DCs differentiated from PBMo, IL-12 production by DCs, expression of MHC-11 (IA), and IFN-gamma production by DC-stimulated T cells were significantly increased in the L/R injured group (compared to the sham-operated group). After 14 days of reperfusion, there was no between-group differences in the numbers of DCs derived from PBMo, MLR, expression of CD80, CD86, and MHC-II (IA), and production of IL-12, IFN-gamma, and IL-4.

    Conclusions. The increases seen at 2 days of reperfusion may reflect a preparatory step in the renal I/R injury pathway. The relationship between upregulation of DC differentiation and ischemic acute renal failure (ARF) remains to be elucidated. (c) 2005 Elsevier Inc. All rights reserved.
    關聯: JOURNAL OF SURGICAL RESEARCH Volume: 132 Issue: 1 Pages: 104-111
    顯示於類別:[運動教練研究所] 期刊論文

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