文化大學機構典藏 CCUR:Item 987654321/2784
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 47250/51116 (92%)
造访人次 : 14543856      在线人数 : 1513
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于CCUR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/2784


    题名: Modulation of monocyte-derived dendritic cell differentiation is associated with ischemic acute renal failure
    作者: Wu CJ
    Sheu JR
    Chen HH
    Liao HF
    Yang YC
    Yang S
    Chen YJ
    贡献者: 運教所
    关键词: dendritic cells
    ischemia-reperfusion injury
    differentiation
    日期: 2006
    上传时间: 2009-11-20 14:27:20 (UTC+8)
    摘要: Background. Dendritic cells (DCs) play a central role in both stimulating and suppressing immune responses and are impacted by surgical injury, exercise, and other physiological stressors. This study aims to determine whether renal ischemia/reperfusion (L/R) injury alters the differentiation, maturation, and activation of DCs from peripheral blood monocytes (PBMo).
    Materials and methods. Sprague-Dawley (SD) rats were subjected to I/R injury or sham-operated. Creatinine clearance (CCr) was monitored daily during the 14 days of reperfusion that followed the ischemic insult. At 2 and 14 days of reperfusion, the following properties of PBMo derived-DCs were assessed: the amount of generated DCs, surface markers [CD11c, CD80, CD86, and MHC-11 (IA)], and functional status including magnitude of mixed lymphocyte reaction (MLR), production of IL-12 p70 by DCs, and production of IFN-gamma and IL-4 by DC-stimulated T cells.

    Results. CCr was greatly reduced in the injured rats 0 to 4 days after ischemia. Two days after I/R injury to kidney, the numbers of DCs differentiated from PBMo, IL-12 production by DCs, expression of MHC-11 (IA), and IFN-gamma production by DC-stimulated T cells were significantly increased in the L/R injured group (compared to the sham-operated group). After 14 days of reperfusion, there was no between-group differences in the numbers of DCs derived from PBMo, MLR, expression of CD80, CD86, and MHC-II (IA), and production of IL-12, IFN-gamma, and IL-4.

    Conclusions. The increases seen at 2 days of reperfusion may reflect a preparatory step in the renal I/R injury pathway. The relationship between upregulation of DC differentiation and ischemic acute renal failure (ARF) remains to be elucidated. (c) 2005 Elsevier Inc. All rights reserved.
    關聯: JOURNAL OF SURGICAL RESEARCH Volume: 132 Issue: 1 Pages: 104-111
    显示于类别:[運動教練研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbText701检视/开启


    在CCUR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈