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https://irlib.pccu.edu.tw/handle/987654321/2702
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| 题名: | Synthesis and cytotoxic activities of 4,5-diarylisoxazoles |
| 作者: | Sun, Chang-Ming
Lin, Lee-Gin
Yu, Hsi-Jung
Cheng, Chih-Yu
Tsai, Ya-Chuan
Chu, Chi-Wei
Chu, Chi-Wei
Chau, Yat-Pang
Don, Ming-Jaw |
| 贡献者: | 化學系 |
| 关键词: | antimitotic agent
4,5-diarylisoxazole
cytotoxicity |
| 日期: | 2007 |
| 上传时间: | 2009-11-16 10:28:04 (UTC+8) |
| 摘要: | A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC50 value as low as 0.022 and 0.065 nM, respectively. (c) 2006 Elsevier Ltd. All rights reserved |
| 關聯: | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 17 Issue: 4 Pages: 1078-1081 |
| 显示于类别: | [化學系所] 期刊論文
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