Synthesis and cytotoxic activities of 4,5-diarylisoxazoles

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Title:	Synthesis and cytotoxic activities of 4,5-diarylisoxazoles
Authors:	Sun, Chang-Ming Lin, Lee-Gin Yu, Hsi-Jung Cheng, Chih-Yu Tsai, Ya-Chuan Chu, Chi-Wei Chu, Chi-Wei Chau, Yat-Pang Don, Ming-Jaw
Contributors:	化學系
Keywords:	antimitotic agent 4,5-diarylisoxazole cytotoxicity
Date:	2007
Issue Date:	2009-11-16 10:28:04 (UTC+8)
Abstract:	A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC50 value as low as 0.022 and 0.065 nM, respectively. (c) 2006 Elsevier Ltd. All rights reserved
Relation:	BIOORGANIC & MEDICINAL CHEMISTRY LETTERS Volume: 17 Issue: 4 Pages: 1078-1081
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

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