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https://irlib.pccu.edu.tw/handle/987654321/24186
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| 题名: | Effects of supplemental dietary arginine on the exogenous advanced glycosylation end product-induced interleukin-23/interleukin-17 immune response in rats |
| 作者: | Yeh, CL (Yeh, Chiu-Li)
Hu, YM (Hu, Ya-Mei)
Liu, JJ (Liu, Jun-Jen)
Chen, WJ (Chen, Wei-Jao)
Yeh, SL (Yeh, Sung-Ling) |
| 贡献者: | Dept Food & Nutr |
| 关键词: | Arginine
Advanced glycosylation end product
Th17
Foxp3 T-regulatory cell |
| 日期: | 2012-10 |
| 上传时间: | 2013-02-19 14:55:46 (UTC+8) |
| 摘要: | Objectives: Arginine (Arg) is known to possess numerous useful physiological properties and immunomodulatory effects. Th17 cells are a unique T-helper cell lineage. Regulation of Th17 cells plays a significant role in the pathogenesis of inflammatory disorders. This study investigated the effect of Argon the exogenous advanced glycosylation end product (AGE)-induced Th17-mediated immune response.
Methods: Rats were randomly divided into three groups. The control BSA (CB) group was fed a common diet and given a tail vein injection of non-glycated bovine serum albumin (BSA). The control AGE (CA) group was fed the common diet and injected with 2 mg AGE-BSA. Arg-AGE (AA) group was fed the Arg-supplemented diet and injected with 2 mg AGE-BSA. The experimental diets were identical in energy and nutrient distributions except for the amino acid content. Arg provided 2% of the total energy. Tail vein injections and diets were given daily. After 10 d, all rats were sacrificed, and blood samples were collected for further analysis.
Results: The AA group had the highest inducible nitric oxide (NO) synthase expression and plasma NO levels. The percentage of Foxp3 T-regulatory cells in the AA group was lower than those of the CA and CB groups. Transforming growth factor-beta 1, interleukin (IL)-6, and IL-17A gene expression was higher in the AGE-administered groups. The AA group had higher TGF-beta 1 and IL-17A expression than did the CA group.
Conclusion: These results suggest that in a condition of exogenous AGE administration, supplemental dietary Arg resulted in a more pronounced IL-23/IL-17 immune response, possibly by increasing NO secretion. (C) 2012 Elsevier Inc. All rights reserved. |
| 關聯: | NUTRITION 卷: 28 期: 10 頁數: 1063-1067 |
| 显示于类别: | [保健營養學系 ] 期刊論文
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