Effects of supplemental dietary arginine on the exogenous advanced glycosylation end product-induced interleukin-23/interleukin-17 immune response in rats

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Title:	Effects of supplemental dietary arginine on the exogenous advanced glycosylation end product-induced interleukin-23/interleukin-17 immune response in rats
Authors:	Yeh, CL (Yeh, Chiu-Li) Hu, YM (Hu, Ya-Mei) Liu, JJ (Liu, Jun-Jen) Chen, WJ (Chen, Wei-Jao) Yeh, SL (Yeh, Sung-Ling)
Contributors:	Dept Food & Nutr
Keywords:	Arginine Advanced glycosylation end product Th17 Foxp3 T-regulatory cell
Date:	2012-10
Issue Date:	2013-02-19 14:55:46 (UTC+8)
Abstract:	Objectives: Arginine (Arg) is known to possess numerous useful physiological properties and immunomodulatory effects. Th17 cells are a unique T-helper cell lineage. Regulation of Th17 cells plays a significant role in the pathogenesis of inflammatory disorders. This study investigated the effect of Argon the exogenous advanced glycosylation end product (AGE)-induced Th17-mediated immune response. Methods: Rats were randomly divided into three groups. The control BSA (CB) group was fed a common diet and given a tail vein injection of non-glycated bovine serum albumin (BSA). The control AGE (CA) group was fed the common diet and injected with 2 mg AGE-BSA. Arg-AGE (AA) group was fed the Arg-supplemented diet and injected with 2 mg AGE-BSA. The experimental diets were identical in energy and nutrient distributions except for the amino acid content. Arg provided 2% of the total energy. Tail vein injections and diets were given daily. After 10 d, all rats were sacrificed, and blood samples were collected for further analysis. Results: The AA group had the highest inducible nitric oxide (NO) synthase expression and plasma NO levels. The percentage of Foxp3 T-regulatory cells in the AA group was lower than those of the CA and CB groups. Transforming growth factor-beta 1, interleukin (IL)-6, and IL-17A gene expression was higher in the AGE-administered groups. The AA group had higher TGF-beta 1 and IL-17A expression than did the CA group. Conclusion: These results suggest that in a condition of exogenous AGE administration, supplemental dietary Arg resulted in a more pronounced IL-23/IL-17 immune response, possibly by increasing NO secretion. (C) 2012 Elsevier Inc. All rights reserved.
Relation:	NUTRITION 卷: 28 期: 10 頁數: 1063-1067
Appears in Collections:	[Department of Food and Nutrition ] journal articles

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