文化大學機構典藏 CCUR:Item 987654321/24166
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    题名: Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level
    作者: Wu, SM (Wu, Semon)
    Hsu, LA (Hsu, Lung-An)
    Teng, MS (Teng, Ming-Sheng)
    Lin, JF (Lin, Jeng-Feng)
    Chang, HH (Chang, Hsien-Hsun)[ 4 ]
    Sun, YC (Sun, Yu-Chen)[ 7 ]
    Chen, HP (Chen, Hsuan-Pu)[ 8 ]
    Ko, YL (Ko, Yu-Lin)[
    贡献者: Dept Life Sci
    关键词: E-selectin
    Genetic association study
    Polymorphism
    Matrix metalloproteinase 9
    Haplotype
    Interaction
    日期: 2012-11-29
    上传时间: 2013-02-18 16:06:26 (UTC+8)
    摘要: Background: E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals.

    Methods: Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed.

    Results: SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511).

    Conclusion: SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.
    關聯: BMC MEDICAL GENETICS 卷: 13 文獻號碼: 115
    显示于类别:[生命科學系] 期刊論文

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