Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level

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Title:	Association of SELE genotypes/haplotypes with sE-selectin levels in Taiwanese individuals: interactive effect of MMP9 level
Authors:	Wu, SM (Wu, Semon) Hsu, LA (Hsu, Lung-An) Teng, MS (Teng, Ming-Sheng) Lin, JF (Lin, Jeng-Feng) Chang, HH (Chang, Hsien-Hsun)[ 4 ] Sun, YC (Sun, Yu-Chen)[ 7 ] Chen, HP (Chen, Hsuan-Pu)[ 8 ] Ko, YL (Ko, Yu-Lin)[
Contributors:	Dept Life Sci
Keywords:	E-selectin Genetic association study Polymorphism Matrix metalloproteinase 9 Haplotype Interaction
Date:	2012-11-29
Issue Date:	2013-02-18 16:06:26 (UTC+8)
Abstract:	Background: E-selectin is implicated in various inflammatory processes and related disorders. We aimed to investigate the role of SELE-gene genotypes/haplotypes on plasma levels of MMP9 and sE-selectin in Taiwanese individuals. Methods: Five hundred twenty individuals were enrolled. Seven tagging SELE single nucleotide polymorphisms were analyzed. Results: SELE genotypes were found associated with MMP9 and sE-selectin levels. Multivariate analysis identified that the most significant genetic polymorphism (rs5368 genotype) was independently associated with MMP9 levels (P < 0.001). One haplotype (GGAGAGT) was marginally associated with MMP9 levels (P = 0.0490). One SELE SNP, (rs3917406, P = 0.031) was associated with sE-selectin levels after adjusting for MMP9 and sICAM1 levels. Subgroup and interaction analysis revealed association of SELE SNP rs10800469 with sE-selectin levels only in the highest quartile of MMP9 level (P = 0.002, interaction P = 0.023). Haplotype analysis showed one haplotype (AAAAAGC) borderline associated with sE-selectin level (P = 0.0511). Conclusion: SELE genotypes/haplotypes are independently associated with MMP9 and E-selectin levels in Taiwanese individuals. The associations of SELE genotypes/haplotypes with sE-selectin levels are affected by MMP9 levels.
Relation:	BMC MEDICAL GENETICS 卷: 13 文獻號碼: 115
Appears in Collections:	[Department of Biology ] journal articles

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