文化大學機構典藏 CCUR:Item 987654321/24055
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 46867/50733 (92%)
造訪人次 : 11891044      線上人數 : 703
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 查詢小技巧:
  • 您可在西文檢索詞彙前後加上"雙引號",以獲取較精準的檢索結果
  • 若欲以作者姓名搜尋,建議至進階搜尋限定作者欄位,可獲得較完整資料
  • 進階搜尋
    主頁登入上傳說明關於CCUR管理 到手機版


    請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/24055


    題名: Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses
    作者: Cheng, PC (Cheng, P.-C.)
    Lin, CN (Lin, C.-N.)
    Chen, YJ (Chen, Y.-J.)
    Chang, FS (Chang, F.-S.)
    Tsaihong, JC (Tsaihong, J.C.)
    Lee, KM (Lee, K.-M.)
    貢獻者: Grad Inst Sport Coaching Sci
    關鍵詞: CD8-ALPHA(-) DENDRITIC CELLS
    IN-VIVO
    DIFFERENTIAL REGULATION
    GRANULOMA-FORMATION
    CYTOKINE PRODUCTION
    SEPTIC SHOCK
    T-CELLS
    ACTIVATION
    INFECTION
    MACROPHAGES
    日期: 2011-05
    上傳時間: 2013-01-24 11:19:07 (UTC+8)
    摘要: P>Inflammatory responses to microbial products are amplified by a pathway mediated by triggering a receptor expressed on the myeloid cells (TREM)-1. Relatively a few studies have been performed to investigate the role of TREM-1 in macrophage activation in response to parasitic infection. In this study, we delineate the role of the innate immunoreceptor TREM-1 in the parasite Schistosoma mansoni infection model from early to late (chronic) phases of infection. Flow cytometry analysis revealed gradual increase in the production of TREM-1 protein on CD11b+ myeloid cells, with maximum production at 5 weeks p.i. Similar results in the pattern of TREM-1 mRNA expressions in splenic CD11b+ cells from infected mice were obtained by real-time PCR. However, unlike in spleen, the TREM-1 mRNA expression in liver tissue showed no significant increase throughout the infection, including periods of maximum production of parasite eggs. Administration of schistosoma egg homogenate antigen to stimulate J774A.1 cells inhibited TREM-1 expression on the surface, indicating that some substances of the Schistosma eggs may inhibit the expression of TREM-1 on macrophages, lowering the macrophage-mediated inflammatory response of infected hosts.
    關聯: PARASITE IMMUNOLOGY 卷: 33 期: 5 頁數: 276-286
    顯示於類別:[運動教練研究所] 期刊論文

    文件中的檔案:

    檔案 描述 大小格式瀏覽次數
    index.html0KbHTML386檢視/開啟


    在CCUR中所有的資料項目都受到原著作權保護.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋