文化大學機構典藏 CCUR:Item 987654321/24055
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 46867/50733 (92%)
造访人次 : 11887682      在线人数 : 771
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧：
  • 您可在西文检索词汇前后加上"双引号"，以获取较精准的检索结果
  • 若欲以作者姓名搜寻，建议至进阶搜寻限定作者字段，可获得较完整数据
    •  进阶搜寻
    主页 ‧ 登入 ‧ 上传 ‧ 说明 ‧ 关于CCUR ‧ 管理 到手机版


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/24055


    题名: Triggering receptor expressed on myeloid cells (TREM)-1 participates in Schistosoma mansoni inflammatory responses
    作者: Cheng, PC (Cheng, P.-C.)
    Lin, CN (Lin, C.-N.)
    Chen, YJ (Chen, Y.-J.)
    Chang, FS (Chang, F.-S.)
    Tsaihong, JC (Tsaihong, J.C.)
    Lee, KM (Lee, K.-M.)
    贡献者: Grad Inst Sport Coaching Sci
    关键词: CD8-ALPHA(-) DENDRITIC CELLS
    IN-VIVO
    DIFFERENTIAL REGULATION
    GRANULOMA-FORMATION
    CYTOKINE PRODUCTION
    SEPTIC SHOCK
    T-CELLS
    ACTIVATION
    INFECTION
    MACROPHAGES
    日期: 2011-05
    上传时间: 2013-01-24 11:19:07 (UTC+8)
    摘要: P>Inflammatory responses to microbial products are amplified by a pathway mediated by triggering a receptor expressed on the myeloid cells (TREM)-1. Relatively a few studies have been performed to investigate the role of TREM-1 in macrophage activation in response to parasitic infection. In this study, we delineate the role of the innate immunoreceptor TREM-1 in the parasite Schistosoma mansoni infection model from early to late (chronic) phases of infection. Flow cytometry analysis revealed gradual increase in the production of TREM-1 protein on CD11b+ myeloid cells, with maximum production at 5 weeks p.i. Similar results in the pattern of TREM-1 mRNA expressions in splenic CD11b+ cells from infected mice were obtained by real-time PCR. However, unlike in spleen, the TREM-1 mRNA expression in liver tissue showed no significant increase throughout the infection, including periods of maximum production of parasite eggs. Administration of schistosoma egg homogenate antigen to stimulate J774A.1 cells inhibited TREM-1 expression on the surface, indicating that some substances of the Schistosma eggs may inhibit the expression of TREM-1 on macrophages, lowering the macrophage-mediated inflammatory response of infected hosts.
    關聯: PARASITE IMMUNOLOGY 卷: 33 期: 5 頁數: 276-286
    显示于类别:[運動教練研究所] 期刊論文

    文件中的档案:

    档案 描述 大小格式浏览次数
    index.html0KbHTML386检视/开启


    检视Licence

    在CCUR中所有的数据项都受到原著作权保护.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈