Comparison of Immune-Related Gene Expression in Two Chicken Breeds Following Infectious Bronchitis Virus Vaccination

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题名:	Comparison of Immune-Related Gene Expression in Two Chicken Breeds Following Infectious Bronchitis Virus Vaccination
作者:	Chuwatthanakhajorn, Schwann Chang, Chi-Sheng Ganapathy, Kannan Tang, Pin-Chi Chen, Chih-Feng 張啟聖
贡献者:	Department of Animal Science
关键词:	differentially expressed gene immune response traits infectious bronchitis virus vaccination RNA-seq spleen transcriptomic
日期:	2023-05
上传时间:	2024-03-12 15:35:01 (UTC+8)
出版者:	Multidisciplinary Digital Publishing Institute
摘要:	This study aims to identify the immune-related genes and the corresponding biological pathways following infectious bronchitis virus vaccination in Taiwan Country and White Leghorn chicken breeds. Transcriptomic analyses of the spleen of these two breeds were conducted by next-generation sequencing. Compared to White Leghorn chicken, Taiwan Country chicken showed a significantly higher level of anti-infectious bronchitis virus (IBV) antibodies at 14 and 21 days pos vaccination. At 7 days post vaccination, in the Taiwan Country chicken, higher expression of mitogen-activated protein kinase 10, Major histocompatibility complex class 1, and V-set pre-B cell surrogate light chain 3 were found. In contrast, the White Leghorn chicken had a high expression of interleukin 4 induced 1, interleukin 6, and interleukin 22 receptor subunit alpha 2. These findings have highlighted the variations in immune induction between chickens with distinct genetic background and provided biological pathways and specific genes involved in immune responses against live attenuated IBV vaccine.
關聯:	Animals
显示于类别:	[動物科學系 ] 期刊論文

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