The two-stage data envelopment analysis (DEA) network model is utilized in this study for examining the corporate social responsibility and corporate performance of 18 multinational enterprises (MNEs) from 2015 to 2020 in the hospitality and travel industry. The result shows that the indicator of corporate social responsibility, the social pillar score has a positive impact on the profitability efficiency of MNEs in the hospitality and travel industry. Moreover, we found that national culture indulgence and long-term orientation act as moderators in the relationship between corporate social responsibility and corporate performance. This study found that indulgence has a negative impact on the relationship between the social pillar score and sustainability efficiency while long-term orientation has a positive impact on the relationship between the social pillar score and sustainability efficiency. Another finding is that indulgence has a positive impact on the relationship between social pillar score and profitability efficiency while long-term orientation has a negative impact on the relationship between social pillar score and profitability efficiency. Therefore, firms located in high indulgence and short-term orientation could get more favorable in turning social activities into profitability outcomes. Our last finding is long-term orientation has a positive impact on the relationship between environmental pillar score and profitability efficiency. The findings of this research recommend managers of multinational enterprises in the hospitality and travel industry consider cultural differences when they make decisions regarding corporate social activities to help them improve their sustainability and profitability efficiency.