Advancements in the Blood-Brain Barrier Penetrating Nanoplatforms for Brain Related Disease Diagnostics and Therapeutic Applications

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题名:	Advancements in the Blood-Brain Barrier Penetrating Nanoplatforms for Brain Related Disease Diagnostics and Therapeutic Applications
作者:	Thangudu, S (Thangudu, Suresh) Cheng, FY (Cheng, Fong-Yu) Su, CH (Su, Chia-Hao)
贡献者:	化學系
关键词:	nanoparticle blood brain barrier brain tumor Parkinson’ s disease Alzheimer’ s disease stroke
日期:	2020-12
上传时间:	2021-01-19 09:49:13 (UTC+8)
摘要:	Noninvasive treatments to treat the brain-related disorders have been paying more significant attention and it is an emerging topic. However, overcoming the blood brain barrier (BBB) is a key obstacle to most of the therapeutic drugs to enter into the brain tissue, which significantly results in lower accumulation of therapeutic drugs in the brain. Thus, administering the large quantity/doses of drugs raises more concerns of adverse side effects. Nanoparticle (NP)-mediated drug delivery systems are seen as potential means of enhancing drug transport across the BBB and to targeted brain tissue. These systems offer more accumulation of therapeutic drugs at the tumor site and prolong circulation time in the blood. In this review, we summarize the current knowledge and advancements on various nanoplatforms (NF) and discusses the use of nanoparticles for successful cross of BBB to treat the brain-related disorders such as brain tumors, Alzheimer's disease, Parkinson's disease, and stroke.
關聯:	POLYMERS 卷冊: 12 期: 12 文獻號碼: 3055
显示于类别:	[化學系所] 期刊論文

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