Micronization of Three Active Pharmaceutical Ingredients Using the Rapid Expansion of Supercritical Solution Technology

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题名:	Micronization of Three Active Pharmaceutical Ingredients Using the Rapid Expansion of Supercritical Solution Technology
作者:	Fang, CH (Fang, Chun-Hao) Chen, PH (Chen, Pei-Hua) Chen, YP (Chen, Yan-Ping) Tang, M (Tang, Muoi)
贡献者:	化材系
关键词:	Active pharmaceutical ingredients Micronization Rapid expansion of supercritical solution Submicron particles Supercritical fluids
日期:	2020-06
上传时间:	2020-12-11 10:57:29 (UTC+8)
摘要:	The rapid expansion of supercritical solution (RESS) technology was applied to recrystallize and micronize three active pharmaceutical ingredients (APIs) of monobenzone, ethylparaben, and kojic acid. All unprocessed (original) APIs had a large mean particle size over 200 mu m with wide particle size distribution. Supercritical carbon dioxide served as the solvent to extract each API in a high-pressure vessel. The nearly saturated supercritical solution was then expanded through a capillary spray nozzle to ambient pressure state. The APIs were recrystallized in a very short time period. The final API particles with submicron sizes were obtained with much less intensity of crystallinity. The optimal RESS process parameters and the improved result of the in vitro dissolution test for the API of ethylparaben are reported.
關聯:	CHEMICAL ENGINEERING & TECHNOLOGY 卷冊: 43 期: 6 頁數: 1186-1193 特刊: SI
显示于类别:	[化學工程與材料工程學系暨碩士班] 期刊論文

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