Synthesis of coumarin derivatives in a microfluidic flow system employing the Pechmann condensation: A case study

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题名:	Synthesis of coumarin derivatives in a microfluidic flow system employing the Pechmann condensation: A case study
作者:	Liu, LK (Liu, Ling-Kang) Deng, JH (Deng, Jhao-Hong) Guo, YM (Guo, Yang-Ming)
贡献者:	化學系
关键词:	catalyst recovery and reuse Coumarin derivatives ionic liquid microfluidic flow reactions Pechmann condensation
日期:	2020-11
上传时间:	2020-11-27 14:35:37 (UTC+8)
摘要:	For the synthesis of coumarin derivatives using the Pechmann condensation scheme, an acidic ionic liquid catalyst, abbreviated as [EBsImH][HSO4], was prepared from the ring opening of 1,4-butanesultone by 1-ethylimidazole, followed by the addition of 1 equiv. H2SO4(c). The [EBsImH][HSO4]-catalyzed Pechmann condensation reactions proceeded smoothly in a batch setup, with recyclable [EBsImH][HSO4] showing great catalytic activity. The acidic ionic liquid catalyst [EBsImH][HSO4] was recovered from EtOAc/H2O extraction of the product mixture, where the H2O layer was worked up and dried for reuse in consecutive runs of the Pechmann condensation reactions, maintaining >85% conversion for four times. The catalytic reactions were also carried out in a microfluidic flow setup. The flow parameters, the reactant molar amounts, and the additional H2SO4 as a modifying acid catalyst were optimized in the current case study. A minimum conversion rate of 2.8 g/hr of coumarin derivatives was demonstrated.
關聯:	JOURNAL OF THE CHINESE CHEMICAL SOCIETY 早期取閱: NOV 2020
显示于类别:	[化學系所] 期刊論文

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