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https://irlib.pccu.edu.tw/handle/987654321/48736
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| 题名: | Effect of Astaxanthin on the Inhibition of Lipid Accumulation in 3T3-L1 Adipocytes via Modulation of Lipogenesis and Fatty Acid Transport Pathways |
| 作者: | Tsai, MC (Tsai, Mei-Chih)
Huang, SC (Huang, Shih-Chien)
Chang, WT (Chang, Wei-Tang)
Chen, SC (Chen, Shiuan-Chih)
Hsu, CL (Hsu, Chin-Lin |
| 贡献者: | 保健營養學系 |
| 关键词: | astaxanthin
lipogenesis
gene expression |
| 日期: | 2020-08 |
| 上传时间: | 2020-10-28 16:26:38 (UTC+8) |
| 摘要: | Obesity is defined as a condition of excessive fat tissue accumulation. It was the major factor most closely associated with lifestyle-related diseases. In the present study, we investigated the effect of astaxanthin on the inhibition of lipid accumulation in 3T3-L1 adipocytes. 3T3-L1 adipocytes were treated with 0-25 mu g/mL of astaxanthin for 0-48 h. The result indicated that astaxanthin significantly decreased the oil Red O stained material (OROSM), intracellular triglyceride accumulation, and glycerol 3-phosphate dehydrogenase (GPDH) activity in 3T3-L1 adipocytes (p< 0.05). At the molecular level, astaxanthin significantly down-regulated the mRNA expression ofperoxisome proliferator-activated receptor-gamma(PPAR gamma) in 3T3-L1 adipocytes (p< 0.05). Moreover, target genes ofPPAR gamma on the inhibition of lipogenesis, such asAcetyl-CoA carboxylase(ACC),fatty acid synthase(FAS),fatty acid binding protein(aP2),cluster of differentiation 36(CD36), andlipoprotein lipase(LPL) in 3T3-L1 adipocytes were significantly down-regulated at a time-dependent manner (p< 0.05). These results suggested that astaxanthin efficiently suppressed lipid accumulation in 3T3-L1 adipocytes and its action is associated with the down-regulation of lipogenesis-related genes and the triglyceride accumulation in 3T3-L1 adipocytes. Therefore, astaxanthin can be developed as a potential nutraceutical ingredient for the prevention of obesity in a niche market. |
| 關聯: | MOLECULES 卷冊: 25 期: 16 文獻號碼: 3598 |
| 显示于类别: | [保健營養學系 ] 期刊論文
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