文化大學機構典藏 CCUR:Item 987654321/45654
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/45654


    题名: Flunarizine Induced Parkinsonism in Migraine Group: A Nationwide Population-Based Study
    作者: Lin, W (Lin, Wei)
    Lin, CL (Lin, Cheng-Li)
    Hsu, CY (Hsu, Chung Y.)
    Wei, CY (Wei, Cheng-Yu)
    贡献者: 運健系
    关键词: flunarizine
    parkinsonism
    drug-induced parkinsonism
    migraine
    population-based
    日期: 2019-12-19
    上传时间: 2020-01-20 13:48:37 (UTC+8)
    摘要: Background: Flunarizine (Fz) is a first-line prophylactic medication that is widely used in migraine. However, Fz has been recognized as a potential cause of drug-induced parkinsonism for a long time. However, to our knowledge, there has been no population-based subgroup analyses for Fz-induced parkinsonism (FIP) in migraine patients. Methods: Data were obtained from the Taiwan's National Health Insurance Research Database. The study comprised 6,470 migraine patients who were divided into two groups, based on their exposure or non-exposure to Fz. Results: During the study period (2000-2012), the incidence rate of parkinsonism was 1.92 and 8.72 per 1,000 person-years in the control and Fz -treated groups, respectively. In the study population, the adjusted hazard ratio was 4.07 (95% confidence interval CI: 2.84-5.85). In 45-64-year old subjects and >= 65-year old subjects, the risk of FIP was 3.18 times (95% CI = 1.63-6.20) and 4.89 times (95% CI = 3.09-7.72) more than that in the controls. The Fz-treated subjects with comorbidities also had a higher risk (4.54, 95% CI: 3.14-6.57). An average annual cumulative Fz dose > 445 mg was accompanied by the greatest risk of FIP; Fz use for >60 days is a cut-off point for predicting future FIP. Conclusion: At the population level, this study showed a complete picture of FIP in migraine patients. FIP is associated with older age, history of comorbidities, exposure to high-dose of Fz, and longer duration of exposure to Fz.
    關聯: FRONTIERS IN PHARMACOLOGY 卷冊: 10 文獻號碼: 1495
    显示于类别:[運動與健康促進學系] 期刊論文

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