Peach Kernel Oil Downregulates Expression of Tissue Factor and Reduces Atherosclerosis in ApoE knockout Mice

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Title:	Peach Kernel Oil Downregulates Expression of Tissue Factor and Reduces Atherosclerosis in ApoE knockout Mice
Authors:	Hao, EW (Hao, Erwei) Pang, GF (Pang, Guofeng) Du, ZC (Du, Zhengcai) Lai, YH (Lai, Yu-Heng) Chen, JR (Chen, Jung-Ren) Xie, JL (Xie, Jinling) Zhou, K (Zhou, Kai) Hou, XT (Hou, Xiaotao) Hsiao, CD (Hsiao, Chung-Der) Deng, JG (Deng, Jiagang)
Contributors:	化學系
Keywords:	ENDOTHELIAL DYSFUNCTION APOLIPOPROTEIN-E TNF-ALPHA BIOLOGY HYPERCHOLESTEROLEMIA THROMBOSIS EXTRACTS NECROSIS DISEASE GENE
Date:	2019-01-02
Issue Date:	2019-06-25 15:25:17 (UTC+8)
Abstract:	Atherosclerosis is the pathological process in arteries due to the plaque formation that is responsible for several diseases like heart disease, stroke and peripheral arterial disease. In this study, we performed in vitro and in vivo assays to evaluate the potential anti-atherosclerosis activity of peach kernel oil. For the in vitro assay, we incubated human umbilical vein endothelial cells (HUVEC) with tumor necrosis factor- (TNF-) to induce tissue factors (TF, an essential mediator of hemostasis and trigger of thrombosis) elevation. We found that TNF--induced TF elevation was suppressed by peach kernel oil in a dose-dependent manner at both mRNA and protein levels. Peach kernel oil can significantly improve HUVEC viability, protect the endothelial cells, which achieved the goal of prevention of thrombotic diseases. For the in vivo assay, we investigated the effect and mechanism of peach kernel oil on preventing atherosclerotic lesion formation in ApoE knockout mice. Results show that peach kernel oil could reduce total cholesterol, triglyceride, low-density lipoprotein cholesterol levels, elevate the high-density lipoprotein cholesterol level in serum, and reduce the area of the aortic atherosclerotic lesions in high-fat diet fed ApoE knockout mice. Moreover, peach kernel oil treatment can significantly down regulate the expression of TF protein to inhibit the formation of atherosclerotic plaque. In conclusion, peach kernel oil may be a potential health food to prevent atherosclerosis in cardiovascular diseases.
Relation:	Int. J. Mol. Sci. 2019, 20(2), 405
Appears in Collections:	[Department of Chemistry & Graduate Institute of Applied Chemistry ] journal articles

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