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| 題名: | Safe Nanocomposite-Mediated Efficient Delivery of MicroRNA Plasmids for Autosomal Dominant Polycystic Kidney Disease (ADPKD) Therapy |
| 作者: | Tsai, YC (Tsai, Yen-Chang)
Teng, IL (Teng, I-Ling)
Jiang, SS (Jiang, Si-Tse)
Lee, YC (Lee, Yi-Che)
Chiou, YY (Chiou, Yuan-Yow)
Cheng, FY (Cheng, Fong-Yu) |
| 貢獻者: | 化學系 |
| 關鍵詞: | DNA DELIVERY
LIPID NANOPARTICLES
TRANSGENIC MICE
ANTI-MIRNA
EXPRESSION
OVEREXPRESSION
PROGRESSION
PROTEIN
MOUSE |
| 日期: | 2019-05-07 |
| 上傳時間: | 2019-06-25 12:48:02 (UTC+8) |
| 摘要: | There is currently no cure for gene mutation-caused autosomal dominant polycystic kidney disease (ADPKD). Over half of patients with ADPKD eventually develop kidney failure, requiring dialysis or kidney transplantation. Current treatment modalities for ADPKD focus on reducing morbidity and mortality from renal and extrarenal complications of the disease. MicroRNA has been shown to be useful in treating ADPKD. This study combines anti-miR NA plasmids and iron oxide/alginate nanoparticles for conjugation with antikidney antibodies. These nanocomposites can specifically target renal tubular cells, providing a potential treatment for ADPKD. Magnetic resonance imaging and in vivo imaging system results show effective targeting of renal cells. Anti-miRNA plasmids released from the nanocomposites inhibit cell proliferation and cyst formation in the PKD cellular and animal models. The results suggest the novel combination of the anti-miRNA plasmids and nanomaterials provides potential clinical implications for ADPKD treatment. |
| 關聯: | Advanced Healthcare Materials
Volume8, Issue5 March 7, 2019 1801358 |
| 顯示於類別: | [化學系所] 期刊論文
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