文化大學機構典藏 CCUR:Item 987654321/41947
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/41947


    题名: Functional components in Scutellaria barbata D. Don with anti-inflammatory activity on RAW 264.7 cells
    作者: Liu, HL (Liu, Hsin-Lan)
    Kao, TH (Kao, Tsai-Hua)
    Shiau, CY (Shiau, Chyuan-Yuan)
    Chen, BH (Chen, Bing-Huei)
    贡献者: 生活應用科學系暨生活應用科學研究所
    关键词: LIPOPOLYSACCHARIDE-STIMULATED MACROPHAGES
    PRESSURE CHEMICAL-IONIZATION
    PHOTODIODE ARRAY DETECTION
    NF-KAPPA-B
    MASS-SPECTROMETRY
    CHLOROPHYLL-A
    ANTIOXIDANT ACTIVITY
    FLAVONOIDS
    EXTRACTS
    PHEOPHYTIN
    日期: 2018
    上传时间: 2019-01-22 14:25:53 (UTC+8)
    摘要: The objectives of this study were to determine the variety and amount of various functional components in Scutellaria barbata D. Don as well as study their anti-inflammatory activity on RAW 264.7 cells. Both ethanol and ethyl acetate extracts were shown to contain the functional components including phenolics, flavonoids, chlorophylls, and carotenoids, with the former mainly composed of phenolics and flavonoids, and the latter of carotenoids and chlorophylls. Both extracts could significantly inhibit (p < 0.05) the production of lipopolysaccharide-induced nitric oxide, prostaglandin E-2, interlukin-6, and interlukin-1 beta, as well as the expressions of phosphor extracellular signal-regulated kinase and phosphor-c-Jun N-terminal kinase (p-JNK), but failed to retard tumor necrosis factor-alpha expression. Both ethanol and ethyl acetate extracts had a dose-dependent anti-inflammatory activity on RAW 264.7 cells. Furthermore, the anti-inflammatory efficiency can be varied for both ethanol and ethyl acetate extracts, which can be attributed to the presence of different varieties and amounts of functional components, as mentioned above. This finding suggested that S. Barbata extract may be used as an anti-inflammatory agent for possible future biomedical application. Copyright (C) 2017, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
    显示于类别:[生活應用科學系暨生活應用科學研究所] 期刊論文

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