文化大學機構典藏 CCUR:Item 987654321/41945
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    题名: Arsenic induces cardiac rhythm dysfunction and acylcarnitines metabolism perturbation in rats
    作者: Phan, NN (Phan, Nam Nhut)
    Li, KL (Li, Kuan-Lun)
    Lin, YC (Lin, Yen-Chang)
    贡献者: 生物科技研究所
    关键词: ACUTE PROMYELOCYTIC LEUKEMIA
    HEART-FAILURE
    VENTRICULAR-TACHYCARDIA
    HYPERENDEMIC VILLAGE
    ENDEMIC AREA
    SUDDEN-DEATH
    QT INTERVAL
    TAIWAN
    RISK
    EXPOSURE
    日期: 2018
    上传时间: 2019-01-22 14:17:04 (UTC+8)
    摘要: Background: Arsenic has been shown to cause various diseases (such as blackfoot disease, cardiovascular diseases, bladder cancer and skin cancer} in many areas of the world. However, the effects of arsenic on cardiac rhythm functions still lack investigation.

    Methods: In this study, different concentrations of arsenic were orally applied to Sprague Dawley rats in order to examine the relationship between arsenic and cardiovascular rhythm (i.e. long QT) via electrocardiography measurement. In addition, QT correction formulas were used to correct the QT interval. Linear regression analysis was used to examine the correlation between the QT interval and cardiac cycle length, corrected QT and heart rate. A metabolomic approach was applied to study carnitinederived metabolites under arsenic exposure by using an ultra-performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC/Q-TOF MS) system.

    Results: The present findings showed that exposure to arsenic causes QT and corrected (QTc) prolongation and heart rate declines. However, the linear correlation analysis showed that there is no significant correlation between cardiac cycle length and the QT interval in both the uncorrected QT and corrected QT. The expression of acylcarnitine metabolites can be used to discriminate the control and arsenic-treated groups.

    Conclusions: This study provides information concerning the effect of arsenic at different concentrations on cardiac rhythm (such as QT, QTc, and heart rate) but not on cardiac cycle length. The metabolism of acylcarnitine metabolites can be a potential pathway for arsenic-induced cardiac rhythm dysfunction in rats.
    显示于类别:[生物科技研究所 ] 期刊論文

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