文化大學機構典藏 CCUR:Item 987654321/41824
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/41824


    题名: Evaluation of collagen mixture on promoting skin wound healing in zebrafish caused by acetic acid administration
    作者: Xiong, XY (Xiong, Xiao-yun)
    Liu, Y (Liu, Yi)
    Shan, LT (Shan, Le-tian)
    Xu, YQ (Xu, Yi-qiao)
    Liang, J (Liang, Jun)
    Lai, YH (Lai, Yu-Heng)
    Hsiao, CD (Hsiao, Chung-Der)
    贡献者: 化學系
    关键词: IN-VITRO
    ANGIOGENESIS
    BETA
    REGENERATION
    CELLS
    日期: 2018-10-28
    上传时间: 2019-01-16 13:33:57 (UTC+8)
    摘要: The aim of this study is to use zebrafish embryos as a quick platform for wound healing studies. At beginning, we optimized a protocol to induce skin lesion by acetic acid injection. The acetic acid injection induced regional inflammation wound hyperpigmentation by recruiting pigment cells to the wound area. Later, we applied established platform to evaluate the effect of tilapia's collagen peptide mixtures, including demonstration on promoting skin wound healing and eliminating inflammatory response. Results showed that after treating TY001, one of the above fish collagen peptide mixtures, not only repair and proliferation were induced, but also death and apoptosis cells were cleared within cutaneous lesion. Moreover, inflammatory response was suppressed along with collagen mixture treatment. Finally, the TY001-associated signaling was validated by real time-PCR, and numbers of gene associated with tissue repair and vessel proliferation were induced. To sum up, our findings provided a permissive model that may apply to generate a platform for further screening on repair and restoration technology. In addition, the tilapia fish collagen peptide mixture we applied on our model has great potential on developing clinical application on wound healing. (C) 2018 Published by Elsevier Inc.
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