文化大學機構典藏 CCUR:Item 987654321/41815
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    题名: LIPC variants as genetic determinants of adiposity status, visceral adiposity indicators, and triglyceride-glucose (TyG) index-related parameters mediated by serum triglyceride levels
    作者: Teng, MS (Teng, Ming-Sheng)
    Wu, S (Wu, Semon)
    Er, LK (Er, Leay-Kiaw)
    Hsu, LA (Hsu, Lung-An)
    Chou, HH (Chou, Hsin-Hua)
    Ko, YL (Ko, Yu-Lin)
    贡献者: 生命科學系
    关键词: HEPATIC LIPASE GENE
    GENOME-WIDE ASSOCIATION
    INSULIN-RESISTANCE
    ACCUMULATION PRODUCT
    CHOLESTEROL LEVELS
    DIABETES-MELLITUS
    MORTALITY
    HYPERLIPIDEMIA
    OBESITY
    RISK
    日期: 2018-11-06
    上传时间: 2019-01-16 11:51:11 (UTC+8)
    摘要: BackgroundVisceral adiposity indicators and the product of triglyceride and fasting plasma glucose (TyG) index-related parameters are effective surrogate markers for insulin resistance (IR) and are predictors of metabolic syndrome and diabetes mellitus. However, their genetic determinants have not been previously reported. Pleiotropic associations of LIPC variants have been observed in lipid profiles and atherosclerotic cardiovascular diseases. We aimed to investigate LIPC polymorphisms as the genetic determinants of adiposity status, visceral adiposity indicators and TyG index-related parameters.MethodsA total of 592 participants from Taiwan were genotyped for three LIPC single nucleotide polymorphisms (SNPs).ResultsThe LIPC SNPs rs2043085 and rs1532085 were significantly associated with body mass index (BMI), waist circumference (WC), lipid accumulation product, visceral adiposity index, and TyG index-related parameters [including the TyG index, TyG with adiposity status (TyG-BMI), and TyG-WC index], whereas the rs1800588 SNP was only significantly associated with the TyG index. The associations became nonsignificant after further adjustment for serum TG levels. No significant association was observed between any the studied LIPC SNPs and IR status.ConclusionOur data revealed a pleiotropic association between the LIPC variants and visceral adiposity indicators and TyG index-related parameters, which are mediated by serum TG levels.
    显示于类别:[生命科學系] 期刊論文

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