Intravenous Arginine Administration Promotes Proangiogenic Cells Mobilization and Attenuates Lung Injury in Mice with Polymicrobial Sepsis

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Title:	Intravenous Arginine Administration Promotes Proangiogenic Cells Mobilization and Attenuates Lung Injury in Mice with Polymicrobial Sepsis
Authors:	Yeh, CL (Yeh, Chiu-Li) Pai, MH (Pai, Man-Hui) Shih, YM (Shih, Yao-Ming) Shih, JM (Shih, Juey-Ming) Yeh, SL (Yeh, Sung-Ling)
Contributors:	保健營養學系
Keywords:	arginine sepsis proangiogenic cells Angpt/Tie-2 lung injury
Date:	2017-05
Issue Date:	2018-02-23 09:44:29 (UTC+8)
Abstract:	This study investigated the influence of intravenous arginine (Arg) administration on alteration of circulating proangiogenic cells and remote lung injury in a model of polymicrobial sepsis. Mice were assigned to one normal control group (NC) and two sepsis groups that were induced by cecal ligation and puncture (CLP). One of the sepsis groups was injected with saline (SS), whereas the other (SA) was administered with a single bolus of 300 mg Arg/kg body weight via the tail vein 1 h after CLP. Septic mice were sacrificed at either 24 or 48 h after CLP, with their blood and lung tissues collected for analysis. Results showed that septic groups had higher proangiogenic cells releasing factors and proangiogenic cells percentage in blood. Also, concentration of inflammatory cytokines and expression of angiopoietin (Angpt)/Tie-2 genes in lung tissues were upregulated. Arg administration promoted mobilization of circulating proangiogenic cells while it downregulated the production of inflammatory cytokines and expression of Angpt/Tie-2 genes in the lung. The results of this investigation suggested that intravenous administration of Arg shortly after the onset of sepsis enhanced the mobilization of circulating proangiogenic cells, maintained the homeostasis of the Angpt/Tie-2 axis, and attenuated remote organ injury in polymicrobial sepsis.
Relation:	NUTRIENTS 卷: 9 期: 5 文獻號碼: 507
Appears in Collections:	[Department of Food and Nutrition ] journal articles

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