文化大學機構典藏 CCUR:Item 987654321/39374
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    题名: Hyperpolarization-activated cyclic nucleotide-gated gene signatures and poor clinical outcome of cancer patient
    作者: Phan, NN (Nam Nhut Phan)
    Huynh, TT (Tung Thanh Huynh)
    Lin, YC (Lin, Yen-Chang)
    贡献者: 生科所
    关键词: Hyperpolarization-activated cyclic nucleotide-gated channel (HCN channel)
    cancers
    Oncomine
    overall survival
    diagnosis
    prognosis
    日期: 2017-08
    上传时间: 2018-01-30 14:46:46 (UTC+8)
    摘要: Background: We investigated the mRNA expression of hyperpolarization-activated cyclic nucleotidegated genes (HCN1-4) in multiple types and subtypes of cancers.

    Methods: We performed a meta-analysis of public microarray data from Oncomine and NextBio Research databases to discover the mRNA expression level of HCN1-4 in cancers. Survival analysis was also used to investigate the correlation between overexpression of HCN gene family with overall survival rate of cancer patients using Kaplan-Meier Plotter database and PROGgene V2 database.

    Results: HCN genes (HCN1-4) over-expression and under-expression in multiples types of cancers such as CNS and brain cancer, breast cancer, colorectal cancer, melanoma, and lymphoma were found. HCN1 was significantly correlated with low overall survival of breast cancer [hazard ratio (HR) = 7.42, P=0.0019] and colorectal cancer (HR = 1.66, P=0.0071) patients. The lower survival rates of lung cancer (HR = 2.5, P=0.0107), kidney cancer (HR = 1.1, P=0.004) and gastric cancer (HR = 1.33, P=0.0037) patients were significantly correlated with the expression of HCN2. HCN3 was significantly correlated to lower survival rates of breast cancer (HR = 1.65, P=0.0016), and kidney cancer (HR = 1.17, P=0.0049). HCN4 was highly correlated with the lower survival rates of breast cancer of gastric cancer (HR = 1.25, P=0.022), lung cancer (HR = 5.37, P=0.0433) and ovarian cancer (HR = 13.58, P=0.0426).

    Conclusions: These data suggested that HCN genes (HCN1-4) are likely to be potential candidates for cancer diagnosis and prognosis.
    關聯: TRANSLATIONAL CANCER RESEARCH 卷: 6 期: 4 頁碼: 698-+
    显示于类别:[生物科技研究所 ] 期刊論文

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