文化大學機構典藏 CCUR:Item 987654321/39351
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    题名: Xuefu Zhuyu decoction ameliorates obesity, hepatic steatosis, neuroinflammation, amyloid deposition and cognition impairment in metabolically stressed APPswe/PS1dE9 mice
    作者: Yeh, CW (Yeh, Chih-Wen)
    Liu, HK (Liu, Hui-Kang)
    Lin, LC (Lin, Lie-Chwen)
    Liou, KT (Liou, Kou-Tong)
    Huang, YC (Huang, Yung-Cheng)
    Lin, CH (Lin, Chien-Hung)
    Tzeng, TT (Tzeng, Tsai-Teng)
    Shie, FS (Shie, Feng-Shiun)
    Tsay, HJ (Tsay, Huey-Jen)
    Shiao, YJ (Shiao, Young-Ji)
    贡献者: 技擊國術系
    关键词: Metabolic stresses
    Alzheimer's disease
    Xuefu Zhuyu decoction
    Amyloid plaque
    Glia
    Cognitive dysfunction
    日期: 2017-09
    上传时间: 2018-01-25 15:07:16 (UTC+8)
    摘要: Ethnopharmacological relevance: Metabolic syndrome and vascular dysfunction was suggested to be the risk factors for Alzheimer's disease (AD). Xuefu Zhuyu decoction (XZD) is a traditional Chinese medicine used to treat metabolic syndrome and cardiac-cerebral vascular disease. The effects of XZD on ameliorating metabolic syndrome, amyloid-related pathologies and cognitive impairment in an animal model of AD with metabolic stress was investigated.

    Materials and method: The animal model of AD with metabolic stress was created by administrating high-fat diet and a low-dose injection of streptozotocin prior to the appearance of senile plaques in APP/PS1 transgenic mice. The diabesity-associated metabolic changes and AD-related pathological alterations were examined.

    Results: We found that XZD reduced body weight, insulin and leptin level, HOMA-IR, hepatic triglyceride, serum A(342 in the metabolic stressed AD animal. XZD also ameliorated oral glucose tolerant, A beta deposition, astrocyte and microglia activation in the vicinity of plaques, and nesting behavior in the metabolic stressed AD animal.

    Conclusion: The results of this study suggest that XZD is able to reduce the peripheral metabolic stress mediated vascular hypoperfusion, neuroinflammation and AD-related pathology in APP/PSI mice.
    關聯: JOURNAL OF ETHNOPHARMACOLOGY 卷: 209 頁碼: 50-61
    显示于类别:[技擊運動暨國術學系] 期刊論文

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