Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease

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题名:	Resveratrol-loaded nanoparticles conjugated with kidney injury molecule-1 as a drug delivery system for potential use in chronic kidney disease
作者:	Lin, YF (Lin, Yuh-Feng) Lee, YH (Lee, Yu-Hsuan) Hsu, YH (Hsu, Yung-Ho) Chen, YJ (Chen, Yi-Jie) Lin, YF (Lin, Yuan-Feng) Cheng, FY (Cheng, Fong-Yu) Chiu, HW (Chiu, Hui-Wen)
贡献者:	化學系
关键词:	autophagy chronic kidney disease inflammasome kidney injury molecule-1 resveratrol
日期:	2017-11
上传时间:	2018-01-25 13:33:01 (UTC+8)
摘要:	Aim: We used resveratrol (Res)-loaded nanoparticles (Res NPs) as a novel method for improving the pharmacokinetic properties of Res and analyzed the effect of Res NPs in chronic kidney disease (CKD). Materials & methods: We coupled anti-kidney injury molecule-1 antibodies to Res NPs and analyzed safety and efficacy. Results: Res NPs had low toxicity and induced autophagy. Res NPs inhibited the NLRP3 inflammasome and IL-1 beta secretion. Higher NLRP3 expression levels were observed in peripheral blood monocytic cells of CKD patients than healthy individuals. Treatment with kidney injury molecule-1-Res NPs significantly reduced creatinine and protected against tubulointerstitial injury in a murine model of CKD. Conclusion: Res NPs through NLRP3 inflammasome attenuation and autophagy induction may be as a strategy to prevent CKD.
關聯:	NANOMEDICINE 卷: 12 期: 22 頁碼: 2741-2756
显示于类别:	[化學系所] 期刊論文

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