本計劃以PBT (Poly Butylene Terephthalate)聚對苯二甲酸丁二酯不織布膜改進其親水性及生物相容性，在其表面經電漿接枝AA(acrylic acid)丙烯酸聚合而產生－COOH 官能基。然後與(chitosan)幾丁聚醣反應，作為延伸鏈。再接上(heparin)肝素。測試改質後接枝密度及親水性。結果顯示接枝改質後親水性增加，而肝素之接枝可延長血液凝固外，可增加親水性，而三層複合之改質不織布膜可濾除33%白血球，若複合四十幾層將可達99.2%之白血球濾除率。概括而言，本研究的最大之成就為固定化肝素於PBT 不織布表面可有效的改善血液相容性及親水性。
Aiming to improve the hydrophilicity and hemocompatibility of poly(butylenes terephthalate) (PBT) fibers, PBT fibers were treated with oxygen plasma, followed by graft-polymerization of acrylic acid (AA) to introduce carboxyl groups. Subsequently, chitosan and heparin were covalently bonded onto the AA-grafted PBT fibers. The surface graft density of modified PBT fibers was detected by dyeing and the hydrophilicity was evaluated by the contact angle. The results show that by the coupling of chitosan, the heparin-immobilized amount can be significantly increased. Water contact angle decreased with the increased of the amount of immobilized heparin, suggesting the increasing hydrophilicity. The immobilization of heparin could effectively reduce platelet adhesion and prolong the blood coagulation time, thereby improve the blood compatibility of PBT. Furthermore, three layers of the heparin-modified PBT fibers can filter 33% of the white blood cells in the blood. Further does of the heparin-modified PBT nonwovens by 40 layers the filter efficiency to reach 99.2%. Overall results of this study demonstrated that the immobilization of heparin onto the surface of PBT fiber would be beneficial to improve the hydrophilicity and hemocompatibility.
