Experimental investigation for the solubility and micronization of pyridin-4-amine in supercritical carbon dioxide

CCUR > College of Natural Science and Engineering > College of Engineering > Department of Chemical & Materials Engineering > journal articles > Item 987654321/36048

Please use this identifier to cite or link to this item: https://irlib.pccu.edu.tw/handle/987654321/36048

Title:	Experimental investigation for the solubility and micronization of pyridin-4-amine in supercritical carbon dioxide
Authors:	Chen, CT (Chen, Chun-Ta) Lee, CA (Lee, Chen-An) Tang, MO (Tang, Muoi) Chen, YP (Chen, Yan-Ping)
Contributors:	化材系
Keywords:	Solute solubility Pyridin-4-amine Active pharmaceutical ingredient Supercritical carbon dioxide RESS
Date:	2017-03
Issue Date:	2017-04-28 11:14:47 (UTC+8)
Abstract:	Novel solute solubility data of pyridin-4-amine (C5H6N2, also known as 4-aminopyridine or fampridine) in supercritical carbon dioxide are measured in this study. This compound is an active pharmaceutical ingredient (API) for the treatment of neurological disorder, and the Alzheimer's disease. The solubility data at three isotherms (308.2, 318.2 and 328.2 K) are reported for pressures from 10 to 22 MPa. These solubility results are ranged from 2 x 10(5) to 2 x 10(4) mol fraction, and are confirmed as thermodynamically consistent. We further apply the rapid expansion of supercritical solution (RESS) process to micronize this API. At our optimal operation condition, the original API with a mean particle size of 532.3 +/- 236.5 mu m is micronized to 0.32 +/- 0.07 mu m. The RESS processed products are much more uniform and nearly spherical amorphous particles. Finally, an in vitro dissolution test illustrates an enhanced dissolution rate by 2.9 times for the micronized pyridin-4-amine. (C) 2017 Elsevier Ltd. All rights reserved.
Relation:	JOURNAL OF CO2 UTILIZATION 卷: 18 頁碼: 173-180
Appears in Collections:	[Department of Chemical & Materials Engineering] journal articles

Files in This Item:

File	Description	Size	Format
index.html		0Kb	HTML	230	View/Open

View Licence

Loading...