文化大學機構典藏 CCUR:Item 987654321/36019
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    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: https://irlib.pccu.edu.tw/handle/987654321/36019


    题名: Association of ABCG2 rs2231142-A allele and serum uric acid levels in male and obese individuals in a Han Taiwanese population
    作者: Cheng, ST (Cheng, Shih-Tsung)
    Wu, S (Wu, Semon)
    Su, CW (Su, Cheng-Wen)
    Teng, MS (Teng, Ming-Sheng)
    Hsu, LA (Hsu, Lung-An)
    Ko, YL (Ko, Yu-Lin)
    贡献者: 生科系
    关键词: obesity
    polymorphism
    sex
    single nucleotide
    uric acid
    日期: 2017-01
    上传时间: 2017-04-27 10:38:49 (UTC+8)
    摘要: Background/Purpose: Recent studies suggest that hyperuricemia is a potential risk factor for cardiovascular disease (CVD). Hyperuricemia is highly heritable and is associated with sex and body weight. Previous genome-wide association studies have found that the ABCG2 single nucleotide polymorphism (SNP) rs2231142 is an important genetic factor for increased uric acid (UA) levels, and the degree of association between rs2231142 and hyperuricemia is affected by both sex and ethnicity. This investigation aimed to analyze the association between ABCG2 polymorphisms and UA levels, as well as their interactions with sex and obesity in Taiwanese.

    Methods: Two genetic polymorphisms around the ABCG2 gene were genotyped in 459 patients.

    Results: After adjusting for clinical covariates, the rs2231142 SNP was found significantly associated with UA levels using a dominant inheritance model. Patients carrying the rs2231142-A allele had a higher frequency of hyperuricemia than those with the rs2231142-CC allele. Subgroup analysis revealed an association of rs2231142 with UA levels in male or obese patients, and there was no association in nonobese female patients.

    Conclusion: The rs2231142 SNP is associated with serum UA levels and hyperuricemia in Taiwanese patients and it occurs predominantly in male or obese patients. Hyperuricemia might be controlled differently by sex and obesity. Copyright (C) 2016, Formosan Medical Association. Published by Elsevier Taiwan LLC.
    關聯: JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 卷: 116 期: 1 頁碼: 18-23
    显示于类别:[生命科學系] 期刊論文

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